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The principal cytochrome P450 isoenzyme included seems to generally be CYP2E1, with CYP1A2 and CYP3A4 as further pathways. Close to eighty five% of an oral dose appears within the urine within just 24 hrs of administration, most as being the glucuronide conjugate, with tiny amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicit